The e-Journal of Neonatology Research

Your open access, online source for everything in neonatology

Volume 4, Issue 1, Winter 2014

without comments



Starting our Fourth Year… The Ever Changing Landscape of Neonatology Journals

The editors of the e-Journal of Neonatology Research



1.  Neonatal High-Risk Follow-up Clinics: How to Improve Attendance in Very Low Birth Weight Infants

Kousiki Patra, Michelle M Greene, Bertha Perez, and Jean M. Silvestri


2. Effect of Phototherapy on Blood Levels of Endothelin-1 and Nitric Oxide in Hyberbilirubinemic Newborn Infants

Nagla H. Abu Faddan, Nafisa H. R. Abd El-Aziz, Hanan G. Abd El-Azeem, and Tahra Shreif



1. Neonatal Abstinence Syndrome: Disparity between Committee Recommendations and Bedside

Phillip Gordon


2. Nuts and Bolts of Quality Improvement: Performing it Versus Administering it

Jonathan R. Swanson



1. Outcomes of extremely preterm infants following severe intracranial hemorrhage. Davis AS, Hintz SR, Goldstein RF, Ambalavanan N, Bann CM, Stoll BJ, Bell EF, Shankaran S, Laptook AR, Walsh MC, Hale EC, Newman NS, Das A, Higgins RD. J Perinatol. 2013 Dec 26. doi: 10.1038/jp.2013.162.

2Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants. Bolisetty S, Dhawan A, Abdel-Latif M, Bajuk B, Stack J, Lui K; New South Wales and Australian Capital Territory Neonatal Intensive Care Units’ Data Collection. Pediatrics. 2014 Jan;133(1):55-62. doi: 10.1542/peds.2013-0372.

3. Neurodevelopmental outcomes of extremely low birth weight infants with spontaneous intestinal perforation or surgical necrotizing enterocolitis. Wadhawan R, Oh W, Hintz SR, Blakely ML, Das A, Bell EF, Saha S, Laptook AR, Shankaran S, Stoll BJ, Walsh MC, Higgins RD. J Perinatol. 2014 Jan;34(1):64-70. doi: 10.1038/jp.2013.128.

4. The Impact of Late Preterm Birth on Executive Function at Preschool Age. Brumbaugh JE, Hodel AS, Thomas KM. Am J Perinatol. 2013 Jun 17.

I think it may be time for the NICHD to create an online, neurodevelopmental outcomes calculator, given recent studies… Dr Tyson are you out there? PVG

5. Prediction of neonatal outcomes in extremely preterm neonates. Ge WJ, Mirea L, Yang J, Bassil KL, Lee SK, Shah PS; Canadian Neonatal Network. Pediatrics. 2013 Oct;132(4):e876-85. doi: 10.1542/peds.2013-0702.

Canada is moving in that direction already. JS

6. Probiotic Effects on Late-onset Sepsis in Very Preterm Infants: A Randomized Controlled Trial. Jacobs SE, Tobin JM, Opie GF, Donath S, Tabrizi SN, Pirotta M, Morley CJ, Garland SM; ProPrems Study Group. Pediatrics. 2013 Dec;132(6):1055-62. doi: 10.1542/peds.2013-1339.

Have always thought probiotics offered little benefit to breastfed infants who have relatively low NEC risk… may have to rethink that after reading this study. PVG

7. Avoiding endotracheal ventilation to prevent bronchopulmonary dysplasia: a meta-analysis. Fischer HS, Bührer C. Pediatrics. 2013 Nov;132(5):e1351-60. doi: 10.1542/peds.2013-1880.

Sometimes the best studies are compelling reminders of what we already think we know. JS

8. The new 6-unit individualized curriculum for pediatric residents: the perspective of neonatology fellowship program directors. Parker TA, Aucott SW, Bendel CM, Dammann CE, Rice WR, Savich RD, Wertheimer FB, Barry JS. J Perinatol. 2013 Dec;33(12):910-3. doi: 10.1038/jp.2013.101.

9. Approval and perceived impact of duty hour regulations: survey of pediatric program directors. Drolet BC, Whittle SB, Khokhar MT, Fischer SA, Pallant A. Pediatrics. 2013 Nov;132(5):819-24. doi: 10.1542/peds.2013-1045.

You’re barking up the right tree, but I don’t think there is anybody home who will listen… PVG

10. Efficacy of clonidine versus phenobarbital in reducing neonatal morphine sulfate therapy days for neonatal abstinence syndrome. A prospective randomized clinical trial. Surran B, Visintainer P, Chamberlain S, Kopcza K, Shah B, Singh R. J Perinatol. 2013 Dec;33(12):954-9. doi: 10.1038/jp.2013.95.

See our journal club below and PVG’s commentary above


What is the evidence for clonidine versus phenobarbitol as a second drug choice for neonatal abstinence syndrome?

1. Sedatives for opiate withdrawal in newborn infants. Osborn DA, Jeffery HE, Cole MJ. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD002053. doi: 10.1002/14651858.CD002053.pub3.

Cochhrane leans towards Phenobarb.

2. Update on the pharmacologic management of neonatal abstinence syndrome. Bio LL, Siu A, Poon CY.J Perinatol. 2011 Nov;31(11):692-701. doi: 10.1038/jp.2011.116. Epub 2011 Aug 25

Evidence not sufficient to make a choice for  a second drug based on meta-analytic technique.

3. Neonatal drug withdrawal. Hudak ML, Tan RC; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics. Pediatrics. 2012 Feb;129(2):e540-60. doi: 10.1542/peds.2011-3212

AAP does not think evidence is sufficient but only prints clonidine in its table of drug choices 

4. Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. Agthe AG, Kim GR, Mathias KB, Hendrix CW, Chavez-Valdez R, Jansson L, Lewis TR, Yaster M, Gauda EB. Pediatrics. 2009 May;123(5):e849-56. doi: 10.1542/peds.2008-0978.

Clonidine does work…

5. Efficacy of clonidine versus phenobarbital in reducing neonatal morphine sulfate therapy days for neonatal abstinence syndrome. A prospective randomized clinical trial. Surran B, Visintainer P, Chamberlain S, Kopcza K, Shah B, Singh R. J Perinatol. 2013 Dec;33(12):954-9. doi: 10.1038/jp.2013.95.

But Phenobarbital works better than Clonidine in a recent head-to-head randomized trial for time to wean off morphine.


Recommended Neonatal Blogs and Sites by Dr Dr Keith Barrington

Public Health Blog Page at Texas Childrens by Dr Steven Abrams

Neonatology on the Web by Ray Duncan

Neoknowledge by Dr Gautham Suresh

Research Raven – Neonatal Conferences by Good Samaritan

Retrospectoscope – remember the last time experts projected what was going to happen to all these drug exposed infants?

Birth outcome from a prospective, matched study of prenatal crack/cocaine use: I. Interactive and dose effects on health and growth. Eyler FD, Behnke M, Conlon M, Woods NS, Wobie K. Feb;101(2):229-37. Pediatrics. 1998

Birth outcome from a prospective, matched study of prenatal crack/cocaine use: II. Interactive and dose effects on neurobehavioral assessment. Eyler FD, Behnke M, Conlon M, Woods NS, Wobie K.   Feb;101(2):237-41.  Pediatrics. 1998

Nobody thinks in utero drug exposure is a good thing, but living through the unfortunate “crack baby” labeling experience leads me to believe we should be optimistic about human potential to overcome developmental exposures during this current rise of narcotic  (and other drug) exposed babies. PVG


2nd International Conference on Nutrition and Growth, January 30-February 1, 2014 Barcelona, Spain

Specialty Review in Neonatology, February 18-23, 2014; Orlando, FL

NEO: The Conference for Neonatology, February 20-23, 2014; Orlando, FL


International Neonatology Association Conference (INAC 2014) April 3-5, 2014; Valencia, Spain

Baby Steps to the Future Conference (Care of the High Risk Infant), April 10-11, Pensacola FL

Pediatric Academic Societies and Asian Society for Pediatric Research Annual Meeting, May 3-6, 2014; Vancouver, Canada

Association of Women’s Health, Obstetric and Neonatal Nurses 2014 Annual Convention, June 14-18, 2014; Orlando, Florida


There were no rejected manuscript(s) and zero rejected letter(s) for this volume (we will NOT publish specific information about individual rejections).

Written by Dr Phillip Gordon

January 14th, 2014 at 3:39 am

Posted in Uncategorized