The e-Journal of Neonatology Research

Your open access, online source for everything in neonatology

Volume 2, Issue 2, Spring 2012

without comments


What have we accomplished?

Jonathan Swanson and Phillip Gordon


The Quality of Lay Press Reporting on Miracle Babies

Phillip Gordon and Jonathan Swanson

[PDF] (Please use HTML version for full video capability)

What do Neonatologists and NNPs think… about the new AAP recommendations regarding Donor Milk?


Increased Incidence of Necrotizing Enterocolitis in the Winter in Southeastern South Carolina

Sarah N. Taylor, Myla Ebeling, Thomas C. Hulsey, and Carol Wagner


The Evolution of Management of Late Preterm and Term Neonates with Hypoxic Respiratory Failure: A Survey of Present Practices

Satyan Lakshminrusimha, Melissa Carmen, Steven R.  Stuewe, and Jay P. Goldsmith


Possible Adverse Event with Bosentan in an Infant with Pulmonary Hypoplasia Secondary to Oligohydramnios: Case Report and Systematic Review

Jane Reynolds and Song-Gui Yang


Reduction of Hospitalization to 24 hours in Asymptomatic Newborns with Group B Streptococcus Colonized Mothers

Naveed Ur Rehman Durrani, Moghis Ur Rehman, Ahmed Ali Imran, M. Baraa Hamadeh, and Fares Chedid


Critical Congenital Heart Disease Screening with Pulse Oximetry in the Neonatal Intensive Care Unit

Satyan Lakshminrusimha, Stephen Turkovich, Jayasree Nair and Vasanth H.S. Kumar



Post discharge nutrition of the late preterm neonate

Marc Masor


The National Association of Neonatal Nurse Practioners new position statement on 24 hour shifts


Dr William Gill to receive The Spirit of Charity award (New Orleans highest clinician honor)



1. Havranek T, Al-Hosni M, Armbrecht E. Probiotics supplementation increases intestinal blood flow velocity in extremely low birth weight preterm infants. J Perinatol 2012 Mar 22. doi: 10.1038/jp.2012.37.

2. Downes KJ, Narendran V, Meinzen-Derr J, McClanahan S, Akinbi HT. The lost art of intubation: Assessing opportunities for residents to perform neonatal intubation. J Perinatol 2012 Mar 1. doi: 10.1038/jp.2012.17.

3. Christensen RD, Baer VL, Gordon PV, Henry E, Whitaker C, Andres RL, Bennett ST. Reference ranges for lymphocyte counts of neonates: Associations between abnormal counts and outcomes. Pediatrics 2012 Apr 16. [Epub ahead of print]

4. Leaf A, Dorling J, Kempley S, McCormick K, Mannix P, Linsell L, Juszczak E, Brocklehurst P; on behalf of the Abnormal Doppler Enteral Prescription Trial Collaborative Group. Early or delayed enteral feeding for preterm growth-restricted infants: A randomized trial. Pediatrics 2012 Apr 9. [Epub ahead of print]

5. Bueno M, Stevens B, de Camargo PP, Toma E, Krebs VL, Kimura AF. Breast milk and glucose for pain relief in preterm infants: A noninferiority randomized controlled trial. Pediatrics 2012 Apr;129(4):664-70.

6. Mohamed A, Shah PS. Transfusion associated necrotizing enterocolitis: A meta-analysis of observational data. Pediatrics 2012 Mar;129(3):529-40.

7. Zagol K, Lake DE, Vergales B, Moorman ME, Paget-Brown A, Lee H, Rusin CG, Delos JB, Clark MT, Moorman JR, Kattwinkel J. Anemia, apnea of prematurity, and blood transfusions. J Pediatr 2012 Apr 10. [Epub ahead of print]

8. Salvador A, Janeczko M, Porat R, Sekhon R, Moewes A, Schutzman D. Randomized controlled trial of early parenteral nutrition cycling to prevent cholestasis in very low birth weight infants. J Pediatr 2012 Mar 14. [Epub ahead of print]

9. Sosenko IR, Florencia Fajardo M, Claure N, Bancalari E. Timing of patent ductus arteriosus treatment and respiratory outcome in premature infants: A double-blind randomized controlled trial. J Pediatr 2012 Jan 26. [Epub ahead of print]

10. Lake ET, Staiger D, Horbar J, Cheung R, Kenny MJ, Patrick T, Rogowski JA. Association between hospital recognition for nursing excellence and outcomes of very low-birth-weight infants. JAMA 2012; 307:1709-16.

Neonatology Journal Club:

Two forms of “NEC-like disease” that do not fit with normal models of NEC presentation:

This quarter’s journal club is designed to illustrate that there are aberrant subsets of NEC-like disease that do not behave like the majority of NEC when it comes to the timing of presentation or the normal prerequisites of feeding. Understanding that there are specific agents and events that can modify the timing and presentation of NEC is a crucial weapon for the neonatal clinician to have in their NEC prevention arsenal. You never know when the next unrecognized NEC-like disease cluster might show up (and we w0uld be happy to take y0ur sentinel report of it in eJNR if you discover it).

The timing of NEC is consistent with Sartwells model of disease incubation:

González-Rivera R, Culverhouse RC, Hamvas A, Tarr PI, Warner BB. The age of necrotizing enterocolitis onset: an application of Sartwell’s incubation period model. J Perinatol. 2011 Aug;31(8):519-23. doi: 10.1038/jp.2010.193.

Take home message: Timing of most NEC presentation occurs in an inverse exponential relationship to the gestational age at birth

IVIG associated NEC-like disease:

Figueras-Aloy J, Rodríguez-Miguélez JM, Iriondo-Sanz M, Salvia-Roiges MD, Botet-Mussons F, Carbonell-Estrany X. Intravenous immunoglobulin and necrotizing enterocolitis in newborns with hemolytic disease. Pediatrics 2010; 125(1):139-44.

 Navarro M, Negre S, Matoses ML, Golombek SG, Vento M. Necrotizing enterocolitis following the use of intravenous immunoglobulin for haemolytic disease of the newborn. Acta Paediatr 2009; 98(7):1214-7.

Krishnan L, Pathare A. Necrotizing enterocolitis in a term neonate following intravenous immunoglobulin therapy. Indian J Pediatr 2011; 78(6):743-4.

Take home message: IVIG associated disease occurs even earlier than term NEC and with minimal feeds. It occurs most commonly in ABO blood types (versus rH) and they are the only ones thus far who have required surgery or have died. Etiology may be via blood group antibodies in the IVIG attacking enterocytes that express the antigen (editor’s hypothesis).

Simply ThickTM -associated NEC-liked disease:

Woods CW, Oliver T, Lewis K, Yang Q. Development of necrotizing enterocolitis in premature infants receiving thickened feeds using SimplyThick®. J Perinatol 2012; 32(2):150-2.

Take home message: Timing is way after the window predicted by Sartwell’s model of disease incubation. Most likely explanation for this disease is fermentation of natural gum secondary to non-sterile product, resulting in short chain fatty acids that are injurious to the colon, eventually leading to late onset colonic NEC-like disease.


Retrospectoscope: since we have two manuscripts involving off lable iNO therapy, we thought it would be good to link to this document as refresher on when to use iNO.

NIH Consensus Development Conference Statement on Inhaled Nitric Oxide Therapy for Premature Infants (2010)

AAP Policy Statements relevant to Neonatology:

Polin RA, Denson S, Brady MT, and The Committee on Fetus and Newborn and Commitee on Infectious Diseases. Strategies for Prevention of Health Care-Associated Infections in the NICU. Pediatrics 2012; 129:e1085-e1093.

Editors note: we are disappointed that the committee did not also discuss the importance of uniform caregiver sick leave policy and the potential for NICU caregivers to transmit viral agents when they come to work medicated for viral symptoms rather than taking sick leave. We believe this an important and largely ignored variable for health care-associated infections.

Section on Breastfeeding. Breastfeeding and the Use of Human Milk. Pediatrics 2012; 129:e827-e841.

Grab Basket:

34th Annual Neonatology: The Sick Newborn

Iowa Neonatal Nutrition Course

NEO Forum NJ

VCU is hiring NEOs


There were no rejected manuscripts and zero rejected commentaries for this volume (we will NOT publish specific information about individual rejections).

Written by Dr Phillip Gordon

April 26th, 2012 at 7:18 pm

Posted in Uncategorized

Leave a Reply