A Virtual Bomb Blast in the Neonatal Research Community

The editors of the e-Journal of Neonatology Research

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What do Neos think are the best oxygen ranges to prevent ROP and death in premature infants <28 weeks gestation at birth?

ORIGINAL RESEARCH AND REVIEWS

1.  Emerging Use of Therapeutic Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy

Robert Newell, Reese H. Clark, Dan Ellsbury, Robert Ursprung, P. Brian Smith, C. Michael Cotten, and Alan R. Spitzer

[PDF]

2. Paul R. Swyer: The Beginnings of Canadian Neonatology at The Hospital for Sick Children in Toronto and Reflections on His Early Career

Corey Nason Reese and Jeff Reese

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COMMENTARIES – this issue is devoted to documentation of the SUPPORT controversy through on-line links

The SUPPORT trial. (http://www.nejm.org/doi/pdf/10.1056/NEJMoa0911781)

OHRP rules against SUPPORT (http://www.hhs.gov/ohrp/detrm_letrs/YR13/mar13a.pdf)

Public Citizen’s first letter to Kathleen Sebelius on April 10th (http://www.citizen.org/documents/2111.pdf)

Public Citizen writes to Richard Marchase on April 11th (http://www.citizen.org/documents/2112.pdf)

The New York Times weighs in (http://www.nytimes.com/2013/04/16/opinion/an-ethical-breakdown-in-medical-research.html?_r=0)

Public Citizen writes to Kathleen Sebelius again (http://www.citizen.org/documents/2124.pdf)

Public Citizen writes to HHS & OHRP of 7 other neonatal trials with ethical concerns (http://www.citizen.org/documents/2115.pdf)

What Public Citizen writes to its constituents (http://www.citizen.org/Page.aspx?pid=5939)

SUPPORT authors respond in New England Journal of Medicine (http://www.nejm.org/doi/pdf/10.1056/NEJMc1304827)

Links to Editorials Elsewhere

Informed Consent and SUPPORT

Jeffrey M. Drazen, M.D., Caren G. Solomon, M.D., M.P.H., and Michael F. Greene, M.D

Risk, Consent, and SUPPORT

David Magnus, Ph.D., and Arthur L. Caplan, Ph.D.

OHRP and Public Citizen Are Wrong about Neonatal Research on Oxygen Therapy Research

^{EDITORS CHOICE: TOP TEN PUBLICATIONS IN NEONATOLOGY (this quarter)}

1. Targeted neonatal echocardiography (TnECHO) service in a Canadian neonatal intensive care unit: a 4-year experience. El-Khuffash A, Herbozo C, Jain A, Lapointe A, McNamara PJ. J Perinatol. 2013 Apr 25. doi: 10.1038/jp.2013.42.

2. Probiotic administration in congenital heart disease: a pilot study. Ellis CL, Bokulich NA, Kalanetra KM, Mirmiran M, Elumalai J, Haapanen L, Schegg T, Rutledge JC, Raff G, Mills DA, Underwood MA. J Perinatol. 2013 Apr 18. doi: 10.1038/jp.2013.41.

3. Implementation of an electronic data monitoring system decreases the rate of hyperoxic episodes in premature neonates. Ellsworth MA, Carey WA, Li M, Wilson GD, Harris MN, Colby CE. J Perinatol. 2013 Apr 11. doi: 10.1038/jp.2013.36.

5. Cronobacter: an emerging opportunistic pathogen associated with neonatal meningitis, sepsis and necrotizing enterocolitis. Hunter CJ, Bean JF. J Perinatol. 2013 Mar 28. doi: 10.1038/jp.2013.26.

6. Human milk versus formula after gastroschisis repair: effects on time to full feeds and time to discharge. Kohler JA Sr, Perkins AM, Bass WT. J Perinatol. 2013 Mar 21. doi: 10.1038/jp.2013.27.

7. Prompt Control of an Outbreak Caused by Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae in a Neonatal Intensive Care Unit. Cantey JB, Sreeramoju P, Jaleel M, Treviño S, Gander R, Hynan LS, Hill J, Brown C, Chung W, Siegel JD, Sánchez PJ. J Pediatr. 2013 Apr 10. doi:pii: S0022-3476(13)00266-7. 10.1016/j.jpeds.2013.03.001

9. Physical Examination Instead of Laboratory Tests for Most Infants Born to Mothers Colonized with Group B Streptococcus: Support for the Centers for Disease Control and Prevention’s 2010 Recommendations. Cantoni L, Ronfani L, Da Riol R, Demarini S; Perinatal Study Group of the Region Friuli-Venezia Giulia. J Pediatr. 2013 Mar 8. doi:pii: S0022-3476(13)00109-1. 10.1016/j.jpeds.2013.01.034.

10. Quality of reporting and evidence in american academy of pediatrics guidelines. Isaac A, Saginur M, Hartling L, Robinson JL. Pediatrics. 2013 Apr;131(4):732-8. doi: 10.1542/peds.2012-2027.

^{NEONATOLOGY JOURNAL CLUB}

Ten Noteworthy Neonatology Abstracts at the Pediatric Academic Society Meeting 2013 and why we think so:

1. [1165.2] Should Very Low Birth Weight Infants Receive Enteral Nutrition during Indomethacin or Ibuprofen Treatment of a Patent Ductus Arteriosus?

R. Clyman, A. Wickremasinghe, N. Jhaveri, D. Hassinger, J. Attridge, U. Sanocka, R. Polin, M. Gillam-Krakauer, (Answer – Yes)

2. [2180.4] High-Flow Nasal Cannulae vs. Nasal CPAP for Post-Extubation Respiratory Support of Very Preterm Infants: A Multicenter, Randomized, Non-Inferiority Trial

Brett J. Manley, Louise S. Owen, Lex W. Doyle, Chad C. Andersen, David W. Cartwright, Margo A. Pritchard, Susan M. Donath, Peter G. Davis. (Answer – HFNC not inferior)

3. [3500.6] Randomized Controlled Trial of Limited Versus Traditional Oxygen Strategy during Resuscitation in Preterm Newborns

Vishal S. Kapadia, Lina F. Chalak, Lucy Christie, Rashmin C. Savani, Myra H. Wyckoff. (better outcomes with less oxygen)

4. [2922.311] The Combination Therapy of Phenobarbital and Opiate for Neonatal Abstinence Syndrome

Margaret Cooper, Zubair Aghai, Aparna Roy, William Graessle. (starting phenobarbitol up front was not better than starting when indicated)

5. [2924.474] Changes in Therapy and Outcomes Associated with the Support Trial

Jaclyn LeVan, Luc P. Brion, Lisa A. Wrage, On Behalf of the NICHD (centers have altered their lower ranges since the report of the SUPPORT trial).

6. [3832.536] Prophylactic Erythropoietin Exacerbates Ventilation-Induced Lung and Brain Inflammation in Preterm Lambs

Graeme R. Polglase, Samantha K. Barton, Tim J.M. Moss, Jacqueline Melville, Megan J. Wallace, Valerie Zahra, Stuart B. Hooper, Mary Tolcos. (animal model sounds a warning)

7. [3838.618] Elevated Immunoreactive Trypsinogen in Very Low Birth Weight Infants May Predict Intestinal Perforation

Nicole D. Birge, Kathy Como-Sabetti, Beth-Ann Bloom, Cathy Worwa, Catherine M. Bendel. (not a very large range for detecti0n, but relatively easy and timely to use).

8. [3838.636] A Method To Identify Susceptibility for NEC in Preterm Infants

Puneet Jairath, Kim Doheny, Charles Palmer. (another potentially promising idea).;

9. [33] Getting to Zero: Development of a NEC QI Initiative To Decrease Progression in NEC Severity

Jenny R. Fox, Tazuddin A. Mohammed, Russell R. Moores, Jr., Archana Jayaram, Sharon A. Cone, Karen D. Hendricks-Munoz. (proof of principle)

10. [132] Optimal Heart Rate Cut-Off for Initiation of Chest Compressions during Neonatal Resuscitation

Bobby Mathew, Jayasree Nair, Daniel D. Swartz, Changxing Ma, Vinay Sharma, Sylvia F. Gugino, Carmon Koenigsknecht, Satyan Lakshminrusimha. (nothing happening below 80 bpm)

11. SURPRISE FINDING of the Meeting: The Impact of Different Neonatal Intensive Care Environments on Brain Development and Function in Preterm Infants ~ Roberta Pineda, Jeffrey Neil, Donna Dierker, Chris Smyser, Hiroyuki Kidokoro, Lauren Reynolds, Cynthia Rogers, Amit Mathur, David Van Essen, Terrie Inder (single rooms may not be better after all – note top ten publication # 4 above)

EDITORS’ EXTRAS

Recommended Neonatal Blogs and Sites

NeonatologyResearch.org by Dr Dr Keith Barrington

Public Health Blog Page at Texas Childrens by Dr Steven Abrams

Neonatology on the Web by Ray Duncan

Research Raven – Neonatal Conferences by Good Samaritin

Retrospectoscope – A reminder of where the field was immediately prior to SUPPORT trial completion.

Long term consequences of oxygen therapy in the neonatal period

Alan H. Jobe* and Suhas G. Kallapur

Conferences

2013 Joint Meeting of the Newborn Screening and Genetic Testing Symposium (NBS&GTS) and the International Society for Neonatal Screening (ISNS), May 5-10; Atlanta, GA

neoFORUM 2013, June 6-7; Morristown, NJ

Aspen/ Snowmass Perinatal Biology Symposium “Fetal adaptation to maternal and placental dysfunction” Aug 24-27, 2013; Snowmass CO

Perinatal Research Society September 20-22, 2013; Eaglewood Resort & Spa, Chicago IL

Special Announcement: Young Investigators workshop Application now available for Perinatal Research Society (due June 14th)

Vermont Oxford Network, Annual Meeting and Quality Improvement Congress, Oct 4-7, 2013; Chicago, IL

REJECTIONS

There were no rejected manuscript(s) and zero rejected letter(s) for this volume (we will NOT publish specific information about individual rejections).

We Are Two Years Old!

The editors of the e-Journal of Neonatology Research

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What do Neos think about metrics and the importance of continuous quality improvement in their NICU?

ORIGINAL RESEARCH AND REVIEWS

1. Levels of Nasal CPAP Applied During the Immediate Post-Extubation Phase: A Randomized Controlled Pilot Trial

Ratchada Kitsommart, Angela Kalyn, Noura Al-Saleem, Marianne Janes, and Guilherme M. Sant’Anna

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2. Point of Care Measurement of Hemoglobin and Hematocrit in Newborn Infants Using a Blood Gas Analyzer

Celine Chedid, Aiman Rahmani, Naveed Durrani, Moghis Ur Rehman, Iram Musharraf, and Ahmad Imran

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3. Quantifying the Impact of the e-Journal of Neonatology Research

Jonathan Swanson and Phillip Gordon

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4. Necrotizing Enterocolitis (NEC) and Darwinism (Reviewing the Evolutionary Basis for NEC)

Phillip Gordon

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5. Neonatal Caregiver’s Opinions Regarding NEC as a Zero Tolerance Quality Outcome

Jonathan Swanson, Phillip Gordon, and Susan Orlando

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SUBMITTED COMMENTARIES

Brief Literature Review: How common is accidental decapitation at birth?

The Editors of the e-Journal of Neonatology Research

Kudos to Womens and Infants Hospital of Rhode Island (for the best public service announcment during the recent NorthEast Blizzard). We note an unfortunate counterpoint report in New York City.

The Editors of the e-Journal of Neonatology Research

^{EDITORS CHOICE: TOP TEN PUBLICATIONS IN NEONATOLOGY (this quarter)}

1. Results of a two-center, before and after study of piperacillin-tazobactam versus ampicillin and gentamicin as empiric therapy for suspected sepsis at birth in neonates <1500 g. Chong E, Reynolds J, Shaw J, Forur L, Delmore P, Uner H, Bloom BT, Gordon P. J Perinatol. 2013 Jan 17. doi: 10.1038/jp.2012.169.

2. Prospective crossover comparison between NAVA and pressure control ventilation in premature neonates less than 1500 grams. Stein H, Alosh H, Ethington P, White DB. J Perinatol. 2012 Oct 25. doi: 10.1038/jp.2012.136

3. Congenital heart defects in a large, unselected cohort of monochorionic twins. Pettit KE, Merchant M, Machin GA, Tacy TA, Norton ME. J Perinatol. 2012 Dec 6. doi: 10.1038/jp.2012.145.

5. Late-Onset Sepsis in Very Low Birth Weight Infants from Singleton and Multiple-Gestation Births.Boghossian NS, Page GP, Bell EF, Stoll BJ, Murray JC, Cotten CM, Shankaran S, Walsh MC, Laptook AR, Newman NS, Hale EC, McDonald SA, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 2013 Jan 13. doi:pii: S0022-3476(12)01423-0. 10.1016/j.jpeds.2012.11.089.

6. Meckel Diverticulum in a Premature Infant: Too Tiny But Still Perforates. Smolkin T, Hayari L, Zohar Y, Steinberg R, Makhoul IR. J Pediatr. 2013 Jan 3. doi:pii: S0022-3476(12)01363-7. 10.1016/j.jpeds.2012.11.029. [Epub ahead of print] No abstract available.

7. A Randomized Controlled Trial to Compare Heated Humidified High-Flow Nasal Cannulae with Nasal Continuous Positive Airway Pressure Postextubation in Premature Infants. Collins CL, Holberton JR, Barfield C, Davis PG. J Pediatr. 2012 Dec 19. doi:pii: S0022-3476(12)01291-7. 10.1016/j.jpeds.2012.11.016

9. High Rates of Resolution of Cholestasis in Parenteral Nutrition-Associated Liver Disease with Fish Oil-Based Lipid Emulsion Monotherapy. Premkumar MH, Carter BA, Hawthorne KM, King K, Abrams SA. J Pediatr. 2012 Nov 16. doi:pii: S0022-3476(12)01189-4. 10.1016/j.J Pediatr..2012.10.019.

10. Neurodevelopmental outcomes in the early CPAP and pulse oximetry trial. Vaucher YE, Peralta-Carcelen M, Finer NN, Carlo WA, Gantz MG, Walsh MC, Laptook AR, Yoder BA, Faix RG, Das A, Schibler K, Rich W, Newman NS, Vohr BR, Yolton K, Heyne RJ, Wilson-Costello DE, Evans PW, Goldstein RF, Acarregui MJ, Adams-Chapman I, Pappas A, Hintz SR, Poindexter B, Dusick AM, McGowan EC, Ehrenkranz RA, Bodnar A, Bauer CR, Fuller J, O’Shea TM, Myers GJ, Higgins RD; SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network. N Engl J Med. 2012 Dec 27;367(26):2495-504. doi: 10.1056/NEJMoa1208506.

^{NEONATOLOGY JOURNAL CLUB}

Five studies about antibiotic choice and duration with empiric rule out of sepsis in the newborn period

1. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR.   Empiric Use of Ampicillin and Cefotaxime, Compared With Ampicillin and Gentamicin, for Neonates at Risk for Sepsis Is Associated With an Increased Risk of Neonatal Death Pediatrics. 2006 Jan;117(1):67-74

2. Mtitimila EI, Cooke RW. Antibiotic regimens for suspected early neonatal sepsis. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004495.

3. Alexander VN, Northrup V, Bizzarro MJ. Antibiotic exposure in the newborn intensive care unit and the risk of necrotizing enterocolitis. J Pediatr. 2011 Sep;159(3):392-7. doi: 10.1016/j.jpeds.2011.02.035

4. Stoll BJ, Hansen NI, Sánchez PJ, Faix RG, Poindexter BB, Van Meurs KP, Bizzarro MJ, Goldberg RN, Frantz ID 3rd, Hale EC, Shankaran S, Kennedy K, Carlo WA, Watterberg KL, Bell EF, Walsh MC, Schibler K, Laptook AR, Shane AL, Schrag SJ, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics. 2011 May;127(5):817-26. doi: 10.1542/peds.2010-2217.

5. Chong E, Reynolds J, Shaw J, Forur L, Delmore P, Uner H, Bloom BT, Gordon P. Results of a two-center, before and after study of piperacillin-tazobactam versus ampicillin and gentamicin as empiric therapy for suspected sepsis at birth in neonates <1500 g. J Perinatol. 2013 Jan 17. doi: 10.1038/jp.2012.169.

EDITORS’ EXTRAS

Recommended Neonatal Blogs and Sites

NeonatologyResearch.org by Dr Dr Keith Barrington

Public Health Blog Page at Texas Childrens by Steven Abrams

Neonatology on the Web by Ray Duncan

Research Raven – Neonatal Conferences by Good Samaritin

Retrospectoscope – The 50 year anniversary of Patrick Bouvier Kennedy’s Life and Death

Review of Patrick Bouvier Kennedy’s Death

Video of the Kennedys after the death of Patrick Bouvier Kennedy

Fitting Patrick Bouvier Kennedy into the timeline of early surfactant research

Conferences

NEO:  The Conference for Neonatology, February 19-24, 2013; Orlando, FL

35^th Annual Current Concepts in Neonatal and Pediatric Transport Conference, February 25-27, 2013; Salt Lake City, UT

2nd Evidence-Based Neonatology Conference, March 13 -16, 2013; Cairo, Egypt

Pediatric Academic Societies Annual Meeting, May 4-7, 2013; Washington, DC

2013 Joint Meeting of the Newborn Screening and Genetic Testing Symposium (NBS&GTS) and the International Society for Neonatal Screening (ISNS), May 5-10; Atlanta, GA

neoFORUM 2013, June 6-7; Morristown, NJ

Aspen/ Snowmass Perinatal Biology Symposium “Fetal adaptation to maternal and placental dysfunction” Aug 24-27, 2013; Snowmass CO

Vermont Oxford Network, Annual Meeting and Quality Improvement Congress, Oct 4-7, 2013; Chicago, IL

REJECTIONS

There were no rejected manuscript(s) and zero rejected letter(s) for this volume (we will NOT publish specific information about individual rejections).

Welcome to our Special edition on NEC: There’s Still a Lot to Learn

Jonathan Swanson

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What do Neos think about the feasibility of approaching NEC like we do central line infections (i.e. zero tolerance)?

 ORIGINAL RESEARCH AND REVIEWS

1. Mapping the New World of Necrotizing Enterocolitis (NEC): Review and Opinion

Phillip Gordon, Robert Christensen, Jörn-Hendrik Weitkamp and Akhil Maheshwari

[PDF]

2. Matched Comparison Study of Whole Body Cooling Therapy With and Without a Single Dose of Aminophylline for Improved Renal Function

Euming Chong, Brooke Vergales, Jane Reynolds, Shelley Thibeau, Victor Lunyong, Santina Zanelli, Karen Fairchild, and Phillip Gordon

[PDF]

3. Detailed Analysis of NEC Risks Across a Decade in a Low Incidence NICU: Can We Drive the Incidence of NEC Toward Zero?

Joshua Benjamin, Euming Chong, Jane Reynolds, and Phillip Gordon

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4. Mortality Trends and Cause of Death among Infants Weighing 2.5 kg or more at Birth in an Inner City Hospital over an 18 year Period

Zehra Panjvani, Edgar Torres, Rhina Castillo, and B. K. Rajegowda

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SUBMITTED COMMENTARIES

The Incidence of NEC is Twice as High in Infants with Gastroschisis

Phillip Gordon, Diane Lambert and Robert Christensen

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Extraordinary Service in the Face of Super Storm Sandy

The Editors of the e-Journal of Neonatology Research

^{EDITORS CHOICE: TOP TEN PUBLICATIONS IN NEONATOLOGY (this quarter)}

1. Sabir H, Jary S, Tooley J, Liu X, Thoresen M. Increased Inspired Oxygen in the First Hours of Life is Associated with Adverse Outcome in Newborns Treated for Perinatal Asphyxia with Therapeutic Hypothermia. J Pediatr. 2012 Sep;161(3):409-16. Epub 2012 Apr 18.

2. Aikio O, Metsola J, Vuolteenaho R, Perhomaa M, Hallman M. Transient defect in nitric oxide generation after rupture of fetal membranes and responsiveness to inhaled nitric oxide in very preterm infants with hypoxic respiratory failure. J Pediatr. 2012 Sep;161(3):397-403.e1. Epub 2012 May 1.

4. Mirea L, Sankaran K, Seshia M, Ohlsson A, Allen AC, Aziz K, Lee SK, Shah PS; Canadian Neonatal Network. Treatment of patent ductus arteriosus and neonatal mortality/morbidities: adjustment for treatment selection bias. J Pediatr. 2012 Oct;161(4):689-694.e1.

5. Patel J, Posencheg M, Ades A. Proficiency and retention of neonatal resuscitation skills by pediatric residents. Pediatrics. 2012 Sep;130(3):515-21.

6. Fergusson DA, Hébert P, Hogan DL, LeBel L, Rouvinez-Bouali N, Smyth JA, Sankaran K, Tinmouth A, Blajchman MA, Kovacs L, Lachance C, Lee S, Walker CR, Hutton B, Ducharme R, Balchin K, Ramsay T, Ford JC, Kakadekar A, Ramesh K, Shapiro S. Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial. JAMA. 2012 Oct 10;308(14):1443-51.

8. Al-Wassia H, Alshaikh B, Sauve R. Prophylactic theophylline for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia: a systematic review and meta-analysis of randomized controlled trials. J Perinatol. 2012 Jul 26. [Epub ahead of print]

9. Cheldelin LV, Dunham S, Stewart V. NICU patient satisfaction: how you measure counts. J Perinatol. 2012 Sep 13. [Epub ahead of print]

10. Watson A, Saville B, Lu Z, Walsh W. It is not the ride: inter-hospital transport is not an independent risk factor for intraventricular hemorrhage among very low birth weight infants. J Perinatol. 2012 Oct 4. [Epub ahead of print]

^{NEONATOLOGY JOURNAL CLUB}  

Five excellent contemporary reviews on acquired neonatal gut disease:

1. Mapping the New World of Necrotizing Enterocolitis (NEC): Review and Opinion, Gordon PV, Christensen R, Weitkamp JH, Maheshwari A. e-J Neonatol Res, 2012; 2(4):145-72. http://www.neonatologyresearch.com/?page_id=3094

2. Necrotizing enterocolitis risk: state of the science. Gephart SM, McGrath JM, Effken JA, Halpern MD. Adv Neonatal Care. 2012 Apr;12(2):77-87. Review.

3. New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond. Afrazi A, Sodhi CP, Richardson W, Neal M, Good M, Siggers R, Hackam DJ. Pediatr Res. 2011 Mar;69(3):183-8. Review.

4. Necrotizing enterocolitis. Neu J, Walker WA. N Engl J Med. 2011 Jan 20;364(3):255-64. Review.

5. Understanding intestinal vulnerability to perforation in the extremely low birth weight infant. Gordon PV. Pediatr Res. 2009 Feb;65(2):138-44. Review

 EDITORS’ EXTRAS

Video Link

  Dr David Hackam

  New Research in Necrotizing Enterocolitis – Artificial Intestine a Therapy for NEC?

Retrospectoscope

FDA extends Simply Thick Warning to include risk of life threating bowel disease in all ages (term and preterm)

Grab Bag

The Institute of Medicine’s Summary Report from the Workshop on The Human Microbiome, Diet and Health

ACGME program guidelines for Neonatal Perintal Fellowship Programs – Please note, neonatal fellows will no longer be required to be directly involved in the care of surgical NICU patients in 2013.

The ACGME’s “Next Accreditation System” and the Council for Pediatric Subspecialty’s current response

Carreer Paths in Neonatology by Marlynn Escabado and John Hartline – via the American Academy of Pediatrics

Conferences

Contemporary Forums The Fetus and Newborn:  State of the Art Care  San Francisco, CA October 28-31, 21021

Contemporary Forums Developmental Interventions in Neonatal Care November 7-10, 2012  Orlando, FL

Hot Topics in Neonatology  December 2-4, 2012 Washington, DC

Contemporary Forums:  Developmental Interventions in Neonatal Care November 7-9, 2012 Orlando, FL

NEO:  The Conference for Neonatology   February 19-24, 2013 Orlando, FL

35^th Annual Current Concepts in Neonatal and Pediatric Transport Conference February 25-27, 2013 Salt Lake City, UT

REJECTIONS

There was one rejected manuscript(s) and zero rejected letter(s) for this volume (we will NOT publish specific information about individual rejections).

ORIGINAL RESEARCH AND REVIEWS

Oxygen Therapy during Resuscitation of Preterm Infants: A Retrospective Analysis

Todd Peters, Talkad Raghuveer, Paula Delmore, Carolyn Ahlers-Schmidt, and Barry Bloom

[PDF]

Characteristics, Mortality and Outcome of Acquired Anasarca in the NICU

Joseph B. Philips, III, Joshua J. Lovvorn, Laura H. Nye, and Monica V. Collins

[PDF]

Infants Born to Mothers with Pre-Gestational Diabetes Have a Higher Risk of Developing Neonatal Hypocalcemia

Samrat U. Das and Pratibha Ankola

[PDF]

Neonatal Caregiver’s Use and Belief’s About Donor Milk

Jonathan R. Swanson, Phillip V. Gordon and Susan Orlando

[PDF]

SUBMITTED COMMENTARIES

A Moment of Silence…

Phillip V. Gordon

[PDF]

^{EDITORS’ CHOICE: TOP TEN PUBLICATIONS IN NEONATOLOGY}

1. Goldstein RF, Cotten CM, Shankaran S, Gantz MG, Poole WK, for The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Influence of gestational age on death and neurodevelopmental outcome in premature infants with severe intracranial hemorrhage. J Perinatol. 2012 Jul 19. [Epub ahead of print]

2. Wadhawan R, Oh W, Vohr BV, Saha S, Das A, Bell EF, Laptook A, Shankaran S, Stoll BJ, Walsh MC, Higgins R. Spontaneous intestinal perforation in extremely low birth weight infants: association with indomethacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age. Arch Dis Child Fetal Neonatal Ed. 2012 June 9. [Epub ahead of print]

3. Garner RS, Burchfield DJ. Treatment of presumed hypotension in very low birthweight neonates: effects on regional cerebral oxygenation. Arch Dis Child Fetal Neonatal Ed. 2012 July 10. [Epub ahead of print]

4. Lorch SA, Baiocchi M, Ahlberg CE, Small DS. The differential impact of delivery hospital on the outcomes of premature infants. Pediatrics. 2012 Jul 9. [Epub ahead of print]

5. Bordessoule A, Emeriaud G, Morneau S, Jouvet P, Beck J. Neurally adjusted ventilatory assist improves patient-ventilator interaction in infants as compared with conventional ventilation. Pediatr Res. 2012 May 11. [Epub ahead of print]

6. Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, Yolton K, Gustafson KE, Leach TM, Green C, Bara R, Petrie Huitema CM, Ehrenkranz RA, Tyson JE, Das A, Hammond J, Peralta-Carcelen M, Evans PW, Heyne RJ, Wilson-Costello DE, Vaucher YE, Bauer CR, Dusick AM, Adams-Chapman I, Goldstein RF, Guillet R, Papile LA, Higgins RD; Eunice Kennedy Shriver NICHD Neonatal Research Network. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012; 366(22):2085-92.

7. Todd DA, Wright A, Broom M, Chauhan M, Meskell S, Cameron C, Perdomi AM, Rochefort M, Jardine L, Stewart A, Shadbolt B. Methods of weaning preterm babies <30 weeks gestation off CPAP: A multicentre randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2012; 97(4):F236-40.

8. Janvier A, Farlow B, Wilfond BS. The Experience of Families With Children With Trisomy 13 and 18 in Social Networks. Pediatrics. 2012 Jul 23. [Epub ahead of print]

9. Polin RA and the Committtee on Fetus and Newborn. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012; 129(5):1006-15.

10. McAdams RM, McPherson RJ, Mayock DE, Juul SE. Outcomes of extremely low birth weight infants given early high-dose erythropoietin. J Perinatol. 2012 Jun 21. [Epub ahead of print]

^{NEONATOLOGY JOURNAL CLUB}

Pros and cons of fluconazole prophylaxis in very low birth weight infants:

1. Manzoni P, Mostert M, Latino MA, Pugni L, Stolfi I, Decembrino L, et al. Clinical characteristics and response to prophylactic fluconazole of preterm VLBW neonates with baseline and acquired fungal colonisation in NICU: data from a multicentre RCT. Early Hum Dev. 2012 May;88 Suppl 2:S60-4.

2. Clerihew L, Austin N, McGuire W. Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD003850.

3. Manzoni P, Stolfi I, Pugni L, Decembrino L, Magnani C, Vetrano G, et al. A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. N Engl J Med. 2007 Jun 14;356(24):2483-95.

4. Manzoni P, Leonessa M, Galletto P, Latino MA, Arisio R, Maule M, et al. Routine use of fluconazole prophylaxis in a neonatal intensive care unit does not select natively fluconazole-resistant Candida subspecies. Pediatr Infect Dis J. 2008 Aug;27(8):731-7.

5. Kaufman D, Boyle R, Hazen KC, Patrie JT, Robinson M, Grossman LB. Twice weekly fluconazole prophylaxis for prevention of invasive Candida infection in high-risk infants of <1000 grams birth weight. J Pediatr. 2005 Aug;147(2):172-9.

EDITORS’ EXTRAS

Not all herbs are created equal!

–Marijuana use may increase the risk of delivering preterm

Another reason to argue against bed-sharing

–Co-sleeping increases desaturation events

Neonatal provisions intact in reauthorization of Pediatric Research Equity Act

–Neonatal expert to be on panel of Pediatric Review Committee of the FDA

A bill before Congress to increase medical residency slots

–The bipartisan Physician Shortage Reduction and Graduate Medical Education Accountability and Transparency Act (HR 6352)

Retrospectoscope

Vermont Oxford Study of Oxygen Sat Limits for ROP

Grab Bag

Children’s Hospitals Neonatal Consortium – Fall 2012 Neonatal Symposium

AAP National Conference & Exhibition – Perinatal Section Program

PAS 2013 – Abstracts Submissions Due November 15th

Perinatal Research Society – Oct 14 – 16th 2012

REJECTIONS

There were no rejected manuscript(s) and zero rejected letter(s) for this volume (we will NOT publish specific information about individual rejections).

What have we accomplished?

Jonathan Swanson and Phillip Gordon

[PDF]

The Quality of Lay Press Reporting on Miracle Babies

Phillip Gordon and Jonathan Swanson

[PDF] (Please use HTML version for full video capability)

What do Neonatologists and NNPs think… about the new AAP recommendations regarding Donor Milk?

ORIGINAL RESEARCH AND REVIEWS

Increased Incidence of Necrotizing Enterocolitis in the Winter in Southeastern South Carolina

Sarah N. Taylor, Myla Ebeling, Thomas C. Hulsey, and Carol Wagner

[PDF]

The Evolution of Management of Late Preterm and Term Neonates with Hypoxic Respiratory Failure: A Survey of Present Practices

Satyan Lakshminrusimha, Melissa Carmen, Steven R.  Stuewe, and Jay P. Goldsmith

[PDF]

Possible Adverse Event with Bosentan in an Infant with Pulmonary Hypoplasia Secondary to Oligohydramnios: Case Report and Systematic Review

Jane Reynolds and Song-Gui Yang

[PDF]

Reduction of Hospitalization to 24 hours in Asymptomatic Newborns with Group B Streptococcus Colonized Mothers

Naveed Ur Rehman Durrani, Moghis Ur Rehman, Ahmed Ali Imran, M. Baraa Hamadeh, and Fares Chedid

[PDF]

Critical Congenital Heart Disease Screening with Pulse Oximetry in the Neonatal Intensive Care Unit

Satyan Lakshminrusimha, Stephen Turkovich, Jayasree Nair and Vasanth H.S. Kumar

[PDF]

COMMENTARIES & ANNOUNCEMENTS

Post discharge nutrition of the late preterm neonate

Marc Masor

[PDF]

The National Association of Neonatal Nurse Practioners new position statement on 24 hour shifts

[PDF]

Dr William Gill to receive The Spirit of Charity award (New Orleans highest clinician honor)

[PDF]

^{EDITORS CHOICE: TOP TEN PUBLICATIONS IN NEONATOLOGY}

1. Havranek T, Al-Hosni M, Armbrecht E. Probiotics supplementation increases intestinal blood flow velocity in extremely low birth weight preterm infants. J Perinatol 2012 Mar 22. doi: 10.1038/jp.2012.37.

2. Downes KJ, Narendran V, Meinzen-Derr J, McClanahan S, Akinbi HT. The lost art of intubation: Assessing opportunities for residents to perform neonatal intubation. J Perinatol 2012 Mar 1. doi: 10.1038/jp.2012.17.

3. Christensen RD, Baer VL, Gordon PV, Henry E, Whitaker C, Andres RL, Bennett ST. Reference ranges for lymphocyte counts of neonates: Associations between abnormal counts and outcomes. Pediatrics 2012 Apr 16. [Epub ahead of print]

4. Leaf A, Dorling J, Kempley S, McCormick K, Mannix P, Linsell L, Juszczak E, Brocklehurst P; on behalf of the Abnormal Doppler Enteral Prescription Trial Collaborative Group. Early or delayed enteral feeding for preterm growth-restricted infants: A randomized trial. Pediatrics 2012 Apr 9. [Epub ahead of print]

5. Bueno M, Stevens B, de Camargo PP, Toma E, Krebs VL, Kimura AF. Breast milk and glucose for pain relief in preterm infants: A noninferiority randomized controlled trial. Pediatrics 2012 Apr;129(4):664-70.

6. Mohamed A, Shah PS. Transfusion associated necrotizing enterocolitis: A meta-analysis of observational data. Pediatrics 2012 Mar;129(3):529-40.

7. Zagol K, Lake DE, Vergales B, Moorman ME, Paget-Brown A, Lee H, Rusin CG, Delos JB, Clark MT, Moorman JR, Kattwinkel J. Anemia, apnea of prematurity, and blood transfusions. J Pediatr 2012 Apr 10. [Epub ahead of print]

8. Salvador A, Janeczko M, Porat R, Sekhon R, Moewes A, Schutzman D. Randomized controlled trial of early parenteral nutrition cycling to prevent cholestasis in very low birth weight infants. J Pediatr 2012 Mar 14. [Epub ahead of print]

9. Sosenko IR, Florencia Fajardo M, Claure N, Bancalari E. Timing of patent ductus arteriosus treatment and respiratory outcome in premature infants: A double-blind randomized controlled trial. J Pediatr 2012 Jan 26. [Epub ahead of print]

10. Lake ET, Staiger D, Horbar J, Cheung R, Kenny MJ, Patrick T, Rogowski JA. Association between hospital recognition for nursing excellence and outcomes of very low-birth-weight infants. JAMA 2012; 307:1709-16.

Neonatology Journal Club:

Two forms of “NEC-like disease” that do not fit with normal models of NEC presentation:

This quarter’s journal club is designed to illustrate that there are aberrant subsets of NEC-like disease that do not behave like the majority of NEC when it comes to the timing of presentation or the normal prerequisites of feeding. Understanding that there are specific agents and events that can modify the timing and presentation of NEC is a crucial weapon for the neonatal clinician to have in their NEC prevention arsenal. You never know when the next unrecognized NEC-like disease cluster might show up (and we w0uld be happy to take y0ur sentinel report of it in eJNR if you discover it).

The timing of NEC is consistent with Sartwells model of disease incubation:

González-Rivera R, Culverhouse RC, Hamvas A, Tarr PI, Warner BB. The age of necrotizing enterocolitis onset: an application of Sartwell’s incubation period model. J Perinatol. 2011 Aug;31(8):519-23. doi: 10.1038/jp.2010.193.

Take home message: Timing of most NEC presentation occurs in an inverse exponential relationship to the gestational age at birth

IVIG associated NEC-like disease:

Figueras-Aloy J, Rodríguez-Miguélez JM, Iriondo-Sanz M, Salvia-Roiges MD, Botet-Mussons F, Carbonell-Estrany X. Intravenous immunoglobulin and necrotizing enterocolitis in newborns with hemolytic disease. Pediatrics 2010; 125(1):139-44.

 Navarro M, Negre S, Matoses ML, Golombek SG, Vento M. Necrotizing enterocolitis following the use of intravenous immunoglobulin for haemolytic disease of the newborn. Acta Paediatr 2009; 98(7):1214-7.

Krishnan L, Pathare A. Necrotizing enterocolitis in a term neonate following intravenous immunoglobulin therapy. Indian J Pediatr 2011; 78(6):743-4.

Take home message: IVIG associated disease occurs even earlier than term NEC and with minimal feeds. It occurs most commonly in ABO blood types (versus rH) and they are the only ones thus far who have required surgery or have died. Etiology may be via blood group antibodies in the IVIG attacking enterocytes that express the antigen (editor’s hypothesis).

Simply Thick^TM -associated NEC-liked disease:

Woods CW, Oliver T, Lewis K, Yang Q. Development of necrotizing enterocolitis in premature infants receiving thickened feeds using SimplyThick®. J Perinatol 2012; 32(2):150-2.

Take home message: Timing is way after the window predicted by Sartwell’s model of disease incubation. Most likely explanation for this disease is fermentation of natural gum secondary to non-sterile product, resulting in short chain fatty acids that are injurious to the colon, eventually leading to late onset colonic NEC-like disease.

EDITORS’ EXTRAS

Retrospectoscope: since we have two manuscripts involving off lable iNO therapy, we thought it would be good to link to this document as refresher on when to use iNO.

NIH Consensus Development Conference Statement on Inhaled Nitric Oxide Therapy for Premature Infants (2010)

AAP Policy Statements relevant to Neonatology:

Polin RA, Denson S, Brady MT, and The Committee on Fetus and Newborn and Commitee on Infectious Diseases. Strategies for Prevention of Health Care-Associated Infections in the NICU. Pediatrics 2012; 129:e1085-e1093.

Editors note: we are disappointed that the committee did not also discuss the importance of uniform caregiver sick leave policy and the potential for NICU caregivers to transmit viral agents when they come to work medicated for viral symptoms rather than taking sick leave. We believe this an important and largely ignored variable for health care-associated infections.

Section on Breastfeeding. Breastfeeding and the Use of Human Milk. Pediatrics 2012; 129:e827-e841.

Grab Basket:

34th Annual Neonatology: The Sick Newborn

Iowa Neonatal Nutrition Course

NEO Forum NJ

VCU is hiring NEOs

 REJECTIONS:

There were no rejected manuscripts and zero rejected commentaries for this volume (we will NOT publish specific information about individual rejections).

EDITORS’ SAMPLER

We Are Fired up! (about video manuscripts and the Research Works Act)

[PDF]

What do Neonatologists and NNPs think… about the Research Works Act? Only two questions (about congress legislating science publishing profits).

Letter to Your Congressman Template

[PDF]

Letter for Refusing Manuscript Review Template

[PDF]

ORIGINAL RESEARCH AND REVIEWS

Plasma Prostaglandin E2 and Mesenteric Doppler Flow Measurements After oral and Intravenous Ibuprofen Treatment of Patent Ductus Arteriosus in Preterm Infants: A Pilot Study with Double-blind Randomized Controlled Methodololgy

Véronique G Dorval, Brigitte-Zoé Martin, Myriam Brassar, Sylvain Chemtob, and Antoine Payot

[PDF]

Spontaneous Rhythmic Contractions (Vasomotion) of the Isolated, Pressurized Ductus Arteriosus of Preterm, but Not Term, Fetal Mice

Megan Vucovich, Noah Ehinger, Stanley D. Poole, Fred S. Lamb, and Jeff Reese

[PDF] (Please use HTML version to see embedded video figures)

Prenatal Diagnosis of Isolated Ductus Arteriosus Aneurysms with Spontaneous Neonatal Closure: Case Series with Systematic Review of the Literature and Video-Echocardiography Demonstration

Song-Gui Yung

[PDF] (Please use HTML version to see embedded video figures)

Is Lymphocytosis an Adjunct Predictor of NEC Mortality in Low Gestation Infants?

Phillip Gordon, Shelly Thibeau, Carsten Pennier, Harley Ginsberg, Victor Lunyong, Mathew Cortez, Vincent Adolph, and Robert Christensen

[PDF]

Lymphocytosis at Necrotizing Enterocolitis Presentation is Associated with Higher Mortality, Increased Feeding Volumes and More Formula Exposure  in an 11 year,  Single Center, Retrospective Study

Amy B. Hair, Jonathan R. Swanson, and Joshua T. Attridge

[PDF]

Challenges, guidelines and systematic review of salivary cortisol research in preterm infants

Anita J Mitchell, Jason Chang, Charlotte Yates, and Richard W. Hall

[PDF]

NNP Opinion Survey on 24 Hour Shifts

Susan Orlando

[PDF]

COMMENTARIES

In Memorium for Mary Ellen Avery

[PDF]

The Dr Bill Gill Naming Ceremony at Tulane-Lakeside NICU

[PDF]

^{EDITORS CHOICE: TOP TEN PUBLICATIONS IN NEONATOLOGY}

1. Garner RS, Miller C, Burchfield DJ. Prophylactic indomethacin infusion increases fractional cerebral oxygen extraction in ELBW neonates. J Perinatol 2012 Jan 5. doi: 10.1038/jp.2011.175. [Epub ahead of print]

2. Sehgal A, Ramsden CA, McNamara PJ. Indomethacin impairs coronary perfusion in infants with hemodynamically significant ductus arteriosus. Neonatology 2012;101(1):20-27.

3. Carlo WA, McDonald SA, Fanaroff AA, Vohr BR, Stoll BJ, Ehrenkranz RA, et al, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Association of antenatal chorticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks’ gestation. JAMA 2011; 306(21):2348-2358.

4. Shah TA, Meinzen-Derr J, Gratton T, Steichen J, Donovan EF, Yolton K, et al. Hospital and neurodevelopmental outcomes of extremely low-birth-weight infants with necrotizing enterocolitis and spontaneous intestinal perforation. J Perinatol 2011 Dec 8. doi: 10.1038/jp.2011.176. [Epub ahead of print]

5. Weintraub AS, Ferrara L, Deluca L, Moshier E, Green RS, Oakman E, et al. Antenatal antibiotic exposure in preterm infants with necrotizing enterocolitis. J Perinatol 2011 Dec 8. doi: 10.1038/jp.2011.180. [Epub ahead of print]

6. Ehrenthal DB, Hoffman MK, Jiang X, Ostrum G. Neonatal outcomes after implementation of guidelines limiting elective delivery before 39 weeks of gestation. Obstet Gynecol 2011;118(5):1047-55.

7. Kieler H, Artama M, Engeland A, Ericsson O, Furu K, Gissler M, et al. Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries. BMJ 2012; 244:d8012.

8. Shah SS, Aronson PL, Mohamad Z, Lorch SA. Delayed acyclovir therapy and death among neonates with herpes simplex virus infection. Pediatrics 2011; 128(6):1153-1160.

9. Berrington JE, Hearn RI, Bythell M, Wright C, Embleton ND. Deaths in preterm infants: Changing pathology over 2 decades. J Pediatr 2012; 160(1):49-53.

10. Schmidt B, Anderson PJ, Doyle LW, Dewey D, Grunau RE, Asztalos EV, et al; Caffeine for Apnea of Prematurity (CAP) Trial Investigators. Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity. JAMA 2012; 307(3):275-82.

Neonatology Journal Club:

Gastroschisis - Assessing the Trends in Neurodevelopment and Quality of Life Over Time (with a short lesson about access obstructionism)

* Please note this journal club is also an exercise in testing manuscript availability, cost and timeliness at your institution. This is a limited scenario. An author might face many times this magnitude of difficulty when trying to write a manuscript on such a topic. Please imagine the frustration and cost associated with obtaining topic specific PDFs for nearly every manuscript or grant that a graduate student or career scientist must write in the course of pursuing their research. The open access movement would erase this frustration, whereas the Research Works act would entrench it, potentially forever. Moreover, it is a specific form of government-sanctioned obstructionism, just  for American funded science. How can we compete globally in such an envirnoment? We urge you to write your congressmen and senators and sign the white house petition over this issue without delay (we’ve made it easy, just click to find their email address).

1. Gorra AS, Needelman H, Azarow KS, Roberts HJ, Jackson BJ, Cusick RA. Long-term neurodevelopmental outcomes in children born with gastroschisis: the tiebreaker. J Pediatr Surg 2012; 47(1):125-9.

2. South AP, Marshall DD, Bose CL, Laughon MM. Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis. J Perinatol 2008; 28(10):702-6.

3. Lunzer H, Menardi G, Brezinka C. Long-term follow-up of children with prenatally diagnosed omphalocele and gastroschisis. J Matern Fetal Med 2001; 10(6):385-92.

4. Halsband H, von Schwabe C. [Long term results and quality of life of children with omphalocele and gastroschisis]. Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir 1989:951-5.

5. Lindham S. Long-term results in children with omphalocele and gastroschisis–a follow-up study. Z Kinderchir 1984; 39(3):164-7.

6. Klein MD, Kosloske AM, Hertzler JH. Congenital defects of the abdominal wall. A review of the experience in New Mexico. JAMA 1981; 245(16):1643-6.

EDITORS’ EXTRAS

Retrospectoscope:

NIH-Funded Research Goes Unpublished

One of the many reasons why eJNR was founded

NIH-funded Research to be sold out by  “Research Works” Act (part I)

NIH-funded Research to be sold out by  “Research Works” Act (part II)

NIH-funded Research to be sold out by “Research Works” Act (part III)

Academic Publishing lobbies Congress to censure Open Access

Twin Births On the Rise

One out of every 30 babies is a twin

Oklahoma Insurance Market Excludes Infants < 1 year

Watch what happens in your state

(Update: A new bill hopes to correct this issue)

REJECTIONS

There were two rejected manuscripts and zero rejected commentaries for this volume (we will NOT publish specific information about individual rejections).

eJNR’s First Year: Goals Reached and Our Vision for the Future

[PDF]

CoPS Creates a New Working Group on Subspecialty Clinical Training Certification

[PDF]

What Do Neos Think… (about the use of competencies in medical education)?

[Survey]

ORIGINAL RESEARCH AND REVIEWS

The Increasing Importance of Human Milk Banks

Jan Kennaugh and Laraine Lockhart-Borman

[PDF]

Assessment of Insulin-Like Growth Factor-1 Level in Neonates with Hyperbilirubinemia

Abeer Fathy, Rawia A. Swelam, and Dalia A. Shaheen

[PDF]

The Impact of Incubators on Noise Produced by High-Frequency Oscillatory Ventilation Inside the NICU

Husam Salama, Assma Azzam, Sawan Alomar, and Khalid Abdulhadi

[PDF]

Neonatologists Think Work Hour Restrictions for House Staff are Hurting the Quality of Neonatology

 Jonathan Swanson and Phillip Gordon

[PDF]

SUBMITTED COMMENTARIES

Report on an American Board of Pediatrics Special Meeting about Maintenance of Certification in Neonatology

(Phillip Gordon)

[PDF]

Are We Writing a New Chapter for the House of God?

Victoria Niklas

[PDF]

A Call to Action on Transfusion Related Acute Gut Injury (TRAGI)

Jonathan Blau and Edmund F. La Gamma

[PDF]

^{EDITORS CHOICE: TOP TEN PUBLICATIONS IN NEONATOLOGY}

1. Kimberlin DW, Whitley RJ, Wan W, Powell DA, Storch G, Ahmed A, et al. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Oral acyclovir suppression and neurodevelopment after neonatal herpes. N Engl J Med 2011; 365(14):1284-92.

2. Logan JW, O’Shea TM, Allred EN, Laughon MM, Bose CL, Dammann O, et al; ELGAN Study Investigators. Early postnatal hypotension and developmental delay at 24 months of age among extremely low gestational age newborns. Arch Dis Child Fetal Neonatal Ed 2011; 96(5):F321-8.

3. Verboon-Maciolek MA, Truttmann AC, Groenendaal F, Skranes J, Døllner H, Hunt RW, et al. Development of Cystic Periventricular Leukomalacia in Newborn Infants after Rotavirus Infection. J Pediatr 2011 Oct 6. [Epub ahead of print]

4. INIS Collaborative Group, Brocklehurst P, Farrell B, King A, Juszczak E, Darlow B, et al. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med 2011; 365(13):1201-11.

5. Ewer AK, Middleton LJ, Furmston AT, Bhoyar A, Daniels JP, Thangaratinam S, et al; PulseOx Study Group. Pulse oximetry screening for congenital heart defects in newborn infants (PulseOx): a test accuracy study. Lancet 2011; 378(9793):785-94.

6. Moorman JR, Carlo WA, Kattwinkel J, Schelonka RL, Porcelli PJ, Navarrete CT, et al. Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: a randomized trial. J Pediatr 2011 Aug 10. [Epub ahead of print]

7. Askie LM, Ballard RA, Cutter GR, Dani C, Elbourne D, et al. On behalf of the Meta-analysis of Preterm Patients on Inhaled Nitric Oxide (MAPPiNO) Collaboration. Inhaled Nitric Oxide in Preterm Infants: An Individual-Patient Data Meta-analysis of Randomized Trials. Pediatrics 2011;128(4):729-739.

8. Pinto-Martin JA, Levy SE, Feldman JF, Lorenz JM, Paneth N, Whitaker AH. Prevalence of autism spectrum disorder in adolescents born weighing <2000 grams. Pediatrics 2011 Oct 17. [Epub ahead of print]

9. Kaempf JW, Wu YX, Kaempf AJ, Kaempf AM, Wang L, Grunkemeier G. What happens when the patent ductus arteriosus is treated less aggressively in very low birth weight infants? J Perinatol 2011 Aug 4. [Epub ahead of print]

10. Murphy K, Weiner J. Use of leukocyte counts in evaluation of early-onset neonatal sepsis. Pediatr Infect Dis J 2011 Aug 19. [Epub ahead of print]

BONUS (Published just prior to our publication!)

11. Tam EWY, Chau V, Ferriero DM, Barkovich AJ, Poskitt KJ, Studholme C, et al. Preterm cerebellar growth impairment after postnatal exposure to glucocorticoids. Sci Transl Med 2011; 3(105):105ra105.

^{NEONATOLOGY JOURNAL CLUB}  

Those that do not remember history are doomed to repeat it.

Robertson AF. Reflections on errors in neonatology III. The “experienced” years, 1970 to 2000. J Perinatol. 2003 Apr-May;23(3):240-9. No abstract available. PMID: 12732863

Robertson AF. Reflections on errors in neonatology: II. The “Heroic” years, 1950 to 1970. J Perinatol. 2003 Mar;23(2):154-61. PMID:  12673267

Robertson AF. Reflections on errors in neonatology: I. The “Hands-Off” years, 1920 to 1950. J Perinatol. 2003 Jan;23(1):48-55. PMID:  12556927

Dunn PM. Perinatal lessons from the past. Julius Hess, MD, (1876-1955) and the premature infant. Arch Dis Child Fetal Neonatal Ed. 2001 Sep;85(2):F141-4. (direct access to the article can be http://fn.bmj.com/content/85/2/F141.long)

EDITORS’ EXTRAS

Retrospectoscope

Non-Compete Clauses may not be legal in your hiring contract

Dr Steven Abram’s Archives on Neonatal Nutrition (Texas Children’s Hospital)

Good advice on current nutrition topics

Because people have been contacting us about neonatal recertification…

The ABP Pediatric Diplomat Newsletter

REJECTIONS

There was one rejected manuscript(s) and zero rejected letter(s) for this volume (we will NOT publish specific information about individual rejections).

Its Jam Packed this Time! (The editors highlight this issue)

[PDF]

What is CoPS and Why Should We Care? (An interview with Vicky Norwood)

[PDF]

How the ACGME’s Proposed 2013 Residency Changes May Affect Neonatal Training (a brief summary from eJNR)

[PDF]

CoPS Invitation to Participate in a Survey on the 2013 Residency Changes (includes links to the ACGME documents)

What Do Neos Think? (a survey about the current intern work hours)

Original Research and Review Manuscripts

Randomized Controlled Trials Need Stratification by Types of Acquired Neonatal Intestinal Diseases

Joshua T. Attridge, Santina A. Zanelli, Matthew J. Gurka, and David A. Kaufman

[PDF]

Review of Adverse Perinatal Outcomes Associated with Environmental & Dietary Factors

Euming Chong

[PDF]

Use of a New Doppler Umbilical Cord Clamp to Measure Heart Rate in Newborn Infants in the Delivery Room

Robert P. Lemke, Michael Farrah, and Paul J. Byrne

[PDF]

Does the Duration of Platelet Transfusion Affect Platelet Counts?

Douglas C. Dannaway, Azif Safarulla, and Shahab Noori

[PDF]

Special Section - Maintenance of Certification

Neonatologists’ Opinions of the American Board of Pediatrics Maintenance of Certification Process are not Favorable

Letters to the Editor

The Future of the NICHD Pediatric Trial Network

Katherine Berezny, P. Brian Smith, and Daniel K. Benjamin Jr

[PDF]

Do Clinicians in Your Community Use Mineral Oil During Delivery?

Stacey M. Fink

[PDF]

Making Sense of the Recent Oxygen Saturation Trials

Robert Ursprung

[PDF]

Invitation to the 9th Annual International Congress for Tropical Pediatrics

[PDF]

^{Editors’ Choice: Top 10 publications in neonatology}

1. Wright CJ, Kirpalani H. Targeting Inflammation to Prevent Bronchopulmonary Dysplasia: Can New Insights Be Translated Into Therapies? Pediatrics. 2011 Jun 6.

2. Lorch SA, Maheshwari P, Even-Shoshan O. The impact of certificate of need programs on neonatal intensive care units. J Perinatol. 2011 Apr 28.

3. Park KT, Nespor C, Kerner J Jr. The use of Omegaven in treating parenteral nutrition-associated liver disease. J Perinatol. 2011 Apr;31 Suppl 1:S57-60.

4. Demauro SB, Roberts RS, Davis P, Alvaro R, Bairam A, Schmidt B; Caffeine for Apnea of Prematurity Trial Investigators. Impact of Delivery Room Resuscitation on Outcomes up to 18 Months in Very Low Birth Weight Infants. J Pediatr. 2011 May 16.

5. Lambert DK, Christensen RD, Baer VL, Henry E, Gordon PV, Besner GE, Wilkes J, Wiedmeier SE, Gerday E. Fulminant necrotizing enterocolitis in a multihospital healthcare system. J Perinatol. 2011 May 12.

6. Clark RH, Gordon P, Walker WM, Laughon M, Smith PB, Spitzer AR. Characteristics of patients who die of necrotizing enterocolitis. J Perinatol. 2011 May 19.

7. Chang JJ, Macones GA. Birth Outcomes of Planned Home Births in Missouri: A Population-Based Study. Am J Perinatol. 2011 Mar 4.

8. Laughon M, Bose C, Allred EN, Oʼshea TM, Ehrenkranz RA, Van Marter LJ, Leviton A; for the ELGAN Study Investigators. Patterns of blood protein concentrations of ELGANs classified by three patterns of respiratory disease in the first two postnatal weeks. Pediatr Res. 2011 Jun 3.

9. Ehrenkranz RA, DAS A, Wrage LA, Poindexter BB, Higgins RD, Stoll BJ, Oh W; The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Early Nutrition Mediates the Influence of Severity of Illness on Extremely LBW Infants. Pediatr Res. 2011 Jun;69(6):522-529.

10. Hintz SR, Stevenson DK, Yao Q, Wong RJ, Das A, Van Meurs KP, Morris BH, Tyson JE, Oh W, Poole WK, Phelps DL, McDavid GE, Grisby C, Higgins RD; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (see Acknowledgements in Supporting Information, Data S1). Is phototherapy exposure associated with better or worse outcomes in 501- to 1000-g-birth-weight infants? Acta Paediatr. 2011 Jul;100(7):960-965.

After reading all ten manuscripts, take the CURRENT IN NEONATOLOGY LITERATURE CERTIFICATION TEST (Vol 1, Issue 2).

About non-CME Credit - non-CME credit may be recognized and can be used to supplant limited amounts of CME credit by hospital credentialing boards if its content  is specific to your area of specialty and you petition for that consideration. eJNR will maintain this content on our site so that it can be evaluated by your hospital credentialling board and will post the names of all individuals who  pass on our bulletin board to facilitate independent verification. You may only submit answers once.

^{Neonatology Master Class}

^{Review of Acquired Neonatal Intestinal Diseases and Best Practices}

1. Afrazi A, Sodhi CP, Richardson W, Neal M, Good M, Siggers R, Hackam DJ. New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond. Pediatr Res. 2011 Mar;69(3):183-8.

2.Gordon PV, Swanson JR, Attridge JT, Clark R. Emerging trends in acquired neonatal intestinal disease: is it time to abandon Bell’s criteria? J Perinatol. 2007 Nov;27(11):661-71.

3. Gordon PV. Understanding intestinal vulnerability to perforation in the extremely low birth weight infant. Pediatr Res. 2009 Feb;65(2):138-44.

4. Attridge JT, Clark R, Walker MW, Gordon PV. New insights into spontaneous intestinal perforation using a national data set: (2) two populations of patients with perforations. J Perinatol. 2006 Mar;26(3):185-8.

5. González-Rivera R, Culverhouse RC, Hamvas A, Tarr PI, Warner BB. The age of necrotizing enterocolitis onset: an application of Sartwell’s incubation period model. J Perinatol. 2011 Jan 27.

6. Sullivan S, Schanler RJ, Kim JH, Patel AL, Trawöger R, Kiechl-Kohlendorfer U, Chan GM, Blanco CL, Abrams S, Cotten CM, Laroia N, Ehrenkranz RA, Dudell G, Cristofalo EA, Meier P, Lee ML, Rechtman DJ, Lucas A. An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products. J Pediatr. 2010 Apr;156(4):562-7.e1.

7. Deshpande G, Rao S, Patole S, Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics. 2010 May;125(5):921-30.

8. Christensen RD. Association between red blood cell transfusions and necrotizing enterocolitis. J Pediatr. 2011 Mar;158(3):349-50. Epub 2010 Dec 10.

9. Sola JE, Tepas JJ 3rd, Koniaris LG. Peritoneal drainage versus laparotomy for necrotizing enterocolitis and intestinal perforation: a meta-analysis. J Surg Res. 2010 Jun 1;161(1):95-100.

10. Rees CM, Eaton S, Khoo AK, Kiely EM; Members of NET Trial Group, Pierro A. Peritoneal drainage does not stabilize extremely low birth weight infants with perforated bowel: data from the NET Trial. J Pediatr Surg. 2010 Feb;45(2):324-8; discussion 328-9.

After reading all ten manuscripts, TAKE THE A.N.I.D. KNOWLEDGE CERTIFICATION TEST

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Editor’s Extra’s

Retrospectoscope

Was the real driver behind resident work hour reform, avoidance of house staff unionization?

FDA warning issued for Simply Thick in preterm infants due to 15 cases of late onset NEC

Clinicians advised not to administer Simply Thick to infants under 37 weeks gestation

Standard concentrations of Neonatal Drug Infusions (from the ISMP & VON – click here for chart)

We wonder if you see any problems with this “universal” standards list (click here for 4 question survey)?

The FDA National Drug Shortages Web List

This is where you’ll find the details on drug shortages of PGE, NeoProfen etc., (so you’ll have some idea how much longer you’ll have to live without it).

This is a relatively recent ISMP evaluation of the impact of drug shortages on health care quality.

The TRAGI (Transfusion Related Acute Gut Injury) Registry Site

Rejections

There was no rejected manuscript(s) and zero rejected letter(s) for this volume (we will NOT publish specific information about individual rejections).

What the world of neonatology research publication can be (from the editor’s desk)

.Click for PDF version

What Do Neos Think? (about the recertification process)

Take a 2 minute anonymous survey, designed to see what neonatologists think about the American Board of Pediatric’s approach to recerification.

Original Research Manuscripts

Neonatal Subgaleal Hemorrhage in a Multihospital Healthcare System: Prevalence, Associations, and Outcomes

Robert D. Christensen, Vickie L. Baer, and Erick Henry

.Click for PDF version

Ileal Immunoglobulin Binding by the Neonatal Fc Receptor: A Previously Unrecognized Mechanism of Protection in the Neonatal Rat Model of Necrotizing Enterocolitis?

Jonathan R. Swanson, Tamas Jilling, Jing Lu, Jessica B. Landseadel, Marek Marcinkiewicz, and Phillip V. Gordon

.Click for PDF version

Trends in Surfactant Use in the United States: Changes in Clinical Practice

Andrea N. Trembath, Reese H. Clark, Barry T. Bloom, P. Brian Smith, Carl Bose, and Matthew Laughon

.Click for PDF version

Occludin and Claudin-5 are Comparably Abundant and Co-localized in the Rat’s Blood Brain Barrier from Late Gestation to Adulthood

Abel Guerra, Jonathan M. King, Betty Alajajian, Elif Isgor, and Murat Digicaylioglu

.Click for PDF Version

Letters to the Editor

Phenobarbital for Cholestatic Liver Disease: Is this a Safe and Proven Therapy?

Alexander B. Kenton MD, FAAP and Kaashif Ahmad MD

.Click for PDF version

Regarding Part IV of Recertification in Neonatology:

A Consensus of 69 Academic Neonatology Section Heads

.Click for PDF version

.Click for PDF version

^{Editor’s Choice: Top 10 studies in neonatology}

1 A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele. Adzick NS, Thom EA, Spong CY, Brock JW, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D’Alton ME, Farmer DL; the MOMS Investigators. New England Journal of Medicine.

A prospective, well powered, randomized trial of fetal surgery with neurodevelopmental follow up.

2 Early postnatal hypotension is not associated with indicators of white matter damage or cerebral palsy in extremely low gestational age newborns. Logan JW, O’Shea TM, Allred EN, Laughon MM, Bose CL, Dammann O, Batton DG, Kuban KC, Paneth N, Leviton A. Journal of Perinatology.

A solid secondary analysis of a prospective observational trial designed to test the prevalent belief that lower blood pressures in asymptomatic ELBW infants lead to neurologic injury.

3 Gastrointestinal complications associated with ibuprofen therapy for patent ductus arteriosus. Rao R, Bryowsky K, Mao J, Bunton D, McPherson C, Mathur A. Journal of Perinatology.

The first study to demonstrate an association between early administration of ibuprofen and spontaneous intestinal perforations, suggesting a similar safety profile to that of indomethacin.

4 Cerebral oxygenation is depressed during sleep in healthy term infants when they sleep prone. Wong FY, Witcombe NB, Yiallourou SR, Yorkston S, Dymowski AR, Krishnan L, Walker AM, Horne RS. Pediatrics.

A very intriguing use of NIRS technology to investigate a contributing etiology of SIDS.

5 Antenatal Corticosteroids Promote Survival of Extremely Preterm Infants Born at 22 to 23 Weeks of Gestation. Journal of Pediatrics.

A solid retrospective analysis that gives one pause about waiting until 24 weeks to give antenatal steroids.

6 Neurodevelopmental Outcomes of Triplets or Higher-Order Extremely Low Birth Weight Infants. Wadhawan R, Oh W, Vohr BR, Wrage L, Das A, Bell EF, Laptook AR, Shankaran S, Stoll BJ, Walsh MC, Higgins RD; for the Eunice Kennedy Shriver National Institute of Child Health & Human Development Neonatal Research Network. Pediatrics.

A solid retrospective analysis with an unsurprising result that may help with selective reduction counseling.

7 Statewide NICU Central-Line-Associated Bloodstream Infection Rates Decline After Bundles and Checklists. Schulman J, Stricof R, Stevens TP, Horgan M, Gase K, Holzman IR, Koppel RI, Nafday S, Gibbs K, Angert R, Simmonds A, Furdon SA, Saiman L; the New York State Regional Perinatal Care Centers. Pediatrics.

A before and after study demonstrating that intention based interventions work on the large scale, but site disparities persist despite implementation of such interventions.

8 Does fellowship pay: what is the long-term financial impact of subspecialty training in pediatrics? Rochlin JM, Simon HK. Pediatrics.

A well done analysis of our financial reality.

9 Calcium Absorption in Very Low Birth Weight Infants with and without Bronchopulmonary Dysplasia. Hicks PD, Rogers SP, Hawthorne KM, Chen Z, Abrams SA. Journal of Pediatrics.

A very nice approach to the question of calcium / phosphate metabolism in chronic lung disease.

10 The age of necrotizing enterocolitis onset: an application of Sartwell’s incubation period model. González-Rivera R, Culverhouse RC, Hamvas A, Tarr PI, Warner BB. Journal of Perinatology.

Interesting and potentially useful analysis, made possible by the exclusion of spontaneous intestinal perforations, demonstrating that there is a discrete temporal window within which NEC onset occurs (it’s timing is an inverse logarithmic function to that of gestational age at birth).

Editor’s Extra’s

Retrospectoscope

Revisiting Libby Zion (a review of events from 1996)

Here is the link to make suggestions for the USDA National Breastfeeding Campaign

How many of you would like to see a new emphasis added on the importance of breastmilk  in WIC for those 1 in 8 newborns who are premies?

A Moment for Mechanism (progesterone)

How Progesterone fosters pregnancy (news from the NIH)

Rejections

There was one rejected manuscript(s) and zero rejected letter(s) for this volume (we will NOT publish specific information about individual rejections).